Drug interactions
Cimetidine + Temsirolimus
Severity: Moderate
Cimetidine and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may modestly raise concentrations of temsirolimus and its active metabolite sirolimus. This could increase toxicities such as mucositis, cytopenias and hyperglycemia.
What this interaction means in plain words
Cimetidine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Temsirolimus belongs to Oncology.
Why it happens
Cimetidine inhibits CYP3A4, which metabolizes temsirolimus and sirolimus.
What to do
Monitor for toxicity and consider famotidine instead of cimetidine; avoid strong CYP3A4 inhibitors rather than this weak one.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Cimetidine with Temsirolimus?
MediHelp rates the interaction as moderate. Cimetidine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine may modestly raise concentrations of temsirolimus and its active metabolite sirolimus. This could increase toxicities such as mucositis, cytopenias and hyperglycemia.
How serious is the interaction between Cimetidine and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for toxicity and consider famotidine instead of cimetidine; avoid strong CYP3A4 inhibitors rather than this weak one.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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