Drug interactions
Cimetidine + Zonisamide
Severity: Minor
Cimetidine and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zonisamide is partly metabolized by CYP3A4, so cimetidine could in theory increase its levels. A meaningful clinical effect has not been well documented.
What this interaction means in plain words
Cimetidine and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Zonisamide belongs to Central Nervous System.
Why it happens
Cimetidine may weakly inhibit CYP3A4-mediated metabolism of zonisamide.
What to do
No dose adjustment is generally required. Monitor for sedation, dizziness or other adverse effects if cimetidine is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Cimetidine with Zonisamide?
MediHelp rates the interaction as minor. Cimetidine and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zonisamide is partly metabolized by CYP3A4, so cimetidine could in theory increase its levels. A meaningful clinical effect has not been well documented.
How serious is the interaction between Cimetidine and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required. Monitor for sedation, dizziness or other adverse effects if cimetidine is started or stopped.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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