Drug interactions
Cinacalcet + Crizotinib
Severity: Moderate
Cinacalcet and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may raise cinacalcet levels because cinacalcet is partly cleared via CYP3A4 and CYP2D6. Higher exposure may lead to hypocalcemia, nausea and QT prolongation.
What this interaction means in plain words
Cinacalcet and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, decreasing cinacalcet clearance.
What to do
Monitor serum calcium and parathyroid hormone, and reduce the cinacalcet dose if hypocalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Crizotinib?
MediHelp rates the interaction as moderate. Cinacalcet and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib may raise cinacalcet levels because cinacalcet is partly cleared via CYP3A4 and CYP2D6. Higher exposure may lead to hypocalcemia, nausea and QT prolongation.
How serious is the interaction between Cinacalcet and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and parathyroid hormone, and reduce the cinacalcet dose if hypocalcemia develops.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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