Drug interactions
Cinacalcet + Dacomitinib
Severity: Moderate
Cinacalcet and Dacomitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong inhibitor of CYP2D6, and cinacalcet is a sensitive CYP2D6 substrate and also a CYP2D6 inhibitor. Co-administration can raise cinacalcet exposure and increase adverse effects such as hypocalcemia and nausea.
What this interaction means in plain words
Cinacalcet and Dacomitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Dacomitinib belongs to Oncology.
Why it happens
Inhibition of CYP2D6-mediated metabolism of cinacalcet by dacomitinib.
What to do
Monitor serum calcium and PTH after starting or stopping dacomitinib and reduce the cinacalcet dose if hypocalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Cinacalcet with Dacomitinib?
MediHelp rates the interaction as moderate. Cinacalcet and Dacomitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib is a strong inhibitor of CYP2D6, and cinacalcet is a sensitive CYP2D6 substrate and also a CYP2D6 inhibitor. Co-administration can raise cinacalcet exposure and increase adverse effects such as hypocalcemia and nausea.
How serious is the interaction between Cinacalcet and Dacomitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH after starting or stopping dacomitinib and reduce the cinacalcet dose if hypocalcemia occurs.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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