Drug interactions
Cinacalcet + Eluxadoline
Severity: Moderate
Cinacalcet and Eluxadoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is a strong CYP2D6 inhibitor and could theoretically increase eluxadoline exposure, as eluxadoline's metabolism is incompletely characterized. Higher exposure could increase adverse effects such as constipation, nausea, and pancreatitis risk.
What this interaction means in plain words
Cinacalcet and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Possible inhibition of CYP2D6-mediated metabolism of eluxadoline by cinacalcet.
What to do
Monitor for constipation, abdominal pain and signs of pancreatitis if used together. Stop eluxadoline if severe constipation or pancreatitis symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Other interactions of Eluxadoline
Frequently asked questions
Can I take Cinacalcet with Eluxadoline?
MediHelp rates the interaction as moderate. Cinacalcet and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinacalcet is a strong CYP2D6 inhibitor and could theoretically increase eluxadoline exposure, as eluxadoline's metabolism is incompletely characterized. Higher exposure could increase adverse effects such as constipation, nausea, and pancreatitis risk.
How serious is the interaction between Cinacalcet and Eluxadoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation, abdominal pain and signs of pancreatitis if used together. Stop eluxadoline if severe constipation or pancreatitis symptoms occur.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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