Drug interactions
Cinacalcet + Fluvoxamine
Severity: Moderate
Cinacalcet and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is metabolized by CYP3A4, CYP2D6 and CYP1A2, and fluvoxamine inhibits CYP1A2 strongly and CYP3A4 weakly, so cinacalcet levels may rise. This could cause hypocalcemia, nausea or QT prolongation.
What this interaction means in plain words
Cinacalcet and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Fluvoxamine belongs to Central Nervous System.
Why it happens
Fluvoxamine inhibits CYP1A2 and CYP3A4, reducing cinacalcet metabolism.
What to do
Monitor serum calcium and PTH after starting or stopping fluvoxamine and adjust cinacalcet dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Fluvoxamine?
MediHelp rates the interaction as moderate. Cinacalcet and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinacalcet is metabolized by CYP3A4, CYP2D6 and CYP1A2, and fluvoxamine inhibits CYP1A2 strongly and CYP3A4 weakly, so cinacalcet levels may rise. This could cause hypocalcemia, nausea or QT prolongation.
How serious is the interaction between Cinacalcet and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH after starting or stopping fluvoxamine and adjust cinacalcet dose accordingly.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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