Drug interactions
Cinacalcet + Itraconazole
Severity: Moderate
Cinacalcet and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase cinacalcet exposure, raising the risk of hypocalcaemia, nausea and vomiting. QT prolongation can follow if calcium falls significantly.
What this interaction means in plain words
Cinacalcet and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4, one of the enzymes metabolising cinacalcet.
What to do
Monitor serum calcium and parathyroid hormone, and reduce the cinacalcet dose if hypocalcaemia or intolerance occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Itraconazole?
MediHelp rates the interaction as moderate. Cinacalcet and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase cinacalcet exposure, raising the risk of hypocalcaemia, nausea and vomiting. QT prolongation can follow if calcium falls significantly.
How serious is the interaction between Cinacalcet and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and parathyroid hormone, and reduce the cinacalcet dose if hypocalcaemia or intolerance occurs.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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