Drug interactions
Cinacalcet + Letermovir
Severity: Moderate
Cinacalcet and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and may raise cinacalcet concentrations. Hypocalcemia and gastrointestinal intolerance are the main concerns.
What this interaction means in plain words
Cinacalcet and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Letermovir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 decreases cinacalcet metabolism.
What to do
Monitor serum calcium and PTH during the letermovir course. Reduce the cinacalcet dose if hypocalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Cinacalcet with Letermovir?
MediHelp rates the interaction as moderate. Cinacalcet and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir is a moderate CYP3A inhibitor and may raise cinacalcet concentrations. Hypocalcemia and gastrointestinal intolerance are the main concerns.
How serious is the interaction between Cinacalcet and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH during the letermovir course. Reduce the cinacalcet dose if hypocalcemia occurs.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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