Drug interactions
Cinacalcet + Ribociclib
Severity: Moderate
Cinacalcet and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a CYP3A4 inhibitor and may raise cinacalcet concentrations, although cinacalcet is also cleared by other pathways. Higher exposure could increase hypocalcemia and nausea. Both drugs can also affect QT interval through hypocalcemia or direct effect.
What this interaction means in plain words
Cinacalcet and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4-mediated metabolism of cinacalcet.
What to do
Monitor serum calcium and ECG, particularly QTc, during combined use. Reduce the cinacalcet dose if hypocalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Cinacalcet with Ribociclib?
MediHelp rates the interaction as moderate. Cinacalcet and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a CYP3A4 inhibitor and may raise cinacalcet concentrations, although cinacalcet is also cleared by other pathways. Higher exposure could increase hypocalcemia and nausea. Both drugs can also affect QT interval through hypocalcemia or direct effect.
How serious is the interaction between Cinacalcet and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and ECG, particularly QTc, during combined use. Reduce the cinacalcet dose if hypocalcemia develops.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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