Drug interactions
Cinnarizine + Desflurane
Severity: Moderate
Cinnarizine and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine is a sedating antihistamine and calcium channel blocker that can add to CNS depression and may add to hypotension under anesthesia. Recovery may be prolonged.
What this interaction means in plain words
Cinnarizine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Desflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression via H1 blockade, with additive vasodilatory effects from calcium channel blockade.
What to do
Monitor blood pressure and anesthetic depth, titrate desflurane to effect, and observe for delayed emergence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Desflurane?
MediHelp rates the interaction as moderate. Cinnarizine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine is a sedating antihistamine and calcium channel blocker that can add to CNS depression and may add to hypotension under anesthesia. Recovery may be prolonged.
How serious is the interaction between Cinnarizine and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and anesthetic depth, titrate desflurane to effect, and observe for delayed emergence.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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