Drug interactions
Cinnarizine + Fluphenazine
Severity: Moderate
Cinnarizine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine is a sedating antihistamine and calcium channel blocker that can itself cause drowsiness and extrapyramidal symptoms. With fluphenazine, sedation and parkinsonian features may be worsened.
What this interaction means in plain words
Cinnarizine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive dopamine-blocking effects, since cinnarizine has weak D2 antagonism.
What to do
Monitor for excessive sedation and new or worsening extrapyramidal symptoms, especially in older patients. Reduce the dose or stop cinnarizine if these develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Fluphenazine?
MediHelp rates the interaction as moderate. Cinnarizine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine is a sedating antihistamine and calcium channel blocker that can itself cause drowsiness and extrapyramidal symptoms. With fluphenazine, sedation and parkinsonian features may be worsened.
How serious is the interaction between Cinnarizine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and new or worsening extrapyramidal symptoms, especially in older patients. Reduce the dose or stop cinnarizine if these develop.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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