Drug interactions
Cinnarizine + Hydroxyzine
Severity: Moderate
Cinnarizine and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating antihistamines, so together they can cause excessive drowsiness, dizziness and slowed reaction time. Anticholinergic effects may also add up, particularly in older patients.
What this interaction means in plain words
Cinnarizine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Hydroxyzine belongs to Respiratory.
Why it happens
Additive H1 antihistamine, CNS depressant and antimuscarinic effects.
What to do
Avoid combined use where possible, or reduce doses and counsel about driving and machinery. Monitor older patients for confusion and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Hydroxyzine?
MediHelp rates the interaction as moderate. Cinnarizine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating antihistamines, so together they can cause excessive drowsiness, dizziness and slowed reaction time. Anticholinergic effects may also add up, particularly in older patients.
How serious is the interaction between Cinnarizine and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible, or reduce doses and counsel about driving and machinery. Monitor older patients for confusion and falls.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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