Drug interactions
Cinnarizine + Paliperidone
Severity: Moderate
Cinnarizine and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine is a sedating antihistamine and calcium channel blocker that can cause drowsiness and, rarely, extrapyramidal symptoms. Combined with paliperidone it may add to sedation and to parkinsonian effects.
What this interaction means in plain words
Cinnarizine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Paliperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression, with additive dopamine-blocking effects contributing to extrapyramidal risk.
What to do
Warn patients about drowsiness and monitor for tremor, rigidity or akathisia. Avoid prolonged use of cinnarizine, especially in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Paliperidone?
MediHelp rates the interaction as moderate. Cinnarizine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine is a sedating antihistamine and calcium channel blocker that can cause drowsiness and, rarely, extrapyramidal symptoms. Combined with paliperidone it may add to sedation and to parkinsonian effects.
How serious is the interaction between Cinnarizine and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about drowsiness and monitor for tremor, rigidity or akathisia. Avoid prolonged use of cinnarizine, especially in elderly patients.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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