Drug interactions
Ciprofloxacin + Danicopan
Severity: Minor
Ciprofloxacin and Danicopan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may increase exposure to P-gp substrates. Ciprofloxacin is a modest P-gp substrate, so increases in levels are possible but probably small.
What this interaction means in plain words
Ciprofloxacin and Danicopan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Danicopan belongs to Miscellaneous.
Why it happens
Danicopan inhibition of intestinal and renal P-glycoprotein efflux may raise ciprofloxacin exposure.
What to do
No dose adjustment is usually needed. Monitor for ciprofloxacin adverse effects such as CNS effects or gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Ciprofloxacin with Danicopan?
MediHelp rates the interaction as minor. Ciprofloxacin and Danicopan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits P-glycoprotein and may increase exposure to P-gp substrates. Ciprofloxacin is a modest P-gp substrate, so increases in levels are possible but probably small.
How serious is the interaction between Ciprofloxacin and Danicopan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for ciprofloxacin adverse effects such as CNS effects or gastrointestinal upset.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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