Drug interactions
Ciprofloxacin + Dolasetron
Severity: Moderate
Ciprofloxacin and Dolasetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolasetron prolongs QT interval and ciprofloxacin has a small QT effect, so together they may modestly raise the risk of torsades de pointes. Risk is mostly relevant in patients with other predisposing factors.
What this interaction means in plain words
Ciprofloxacin and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Dolasetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation.
What to do
Check ECG and electrolytes in patients with cardiac disease, electrolyte abnormalities or other QT-prolonging drugs. Consider an alternative antiemetic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Dolasetron?
MediHelp rates the interaction as moderate. Ciprofloxacin and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolasetron prolongs QT interval and ciprofloxacin has a small QT effect, so together they may modestly raise the risk of torsades de pointes. Risk is mostly relevant in patients with other predisposing factors.
How serious is the interaction between Ciprofloxacin and Dolasetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with cardiac disease, electrolyte abnormalities or other QT-prolonging drugs. Consider an alternative antiemetic in high-risk patients.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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