Drug interactions
Ciprofloxacin + Erythromycin lactobionate
Severity: Moderate
Ciprofloxacin and Erythromycin lactobionate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin has notable QT-prolonging effects, and ciprofloxacin adds to this, so torsade de pointes risk may rise. Risk is higher with intravenous macrolide, electrolyte disturbances or structural heart disease.
What this interaction means in plain words
Ciprofloxacin and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade.
What to do
Avoid combining where an alternative exists. If used together, correct potassium and magnesium and obtain an ECG in patients with additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Ciprofloxacin with Erythromycin lactobionate?
MediHelp rates the interaction as moderate. Ciprofloxacin and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin has notable QT-prolonging effects, and ciprofloxacin adds to this, so torsade de pointes risk may rise. Risk is higher with intravenous macrolide, electrolyte disturbances or structural heart disease.
How serious is the interaction between Ciprofloxacin and Erythromycin lactobionate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where an alternative exists. If used together, correct potassium and magnesium and obtain an ECG in patients with additional risk factors.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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