Drug interactions
Ciprofloxacin + Gepirone
Severity: Moderate
Ciprofloxacin and Gepirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so concurrent use may raise the risk of torsades de pointes. Gepirone labeling advises caution with other QT-prolonging drugs.
What this interaction means in plain words
Ciprofloxacin and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Gepirone belongs to Central Nervous System.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Check an ECG and electrolytes, and avoid the combination in patients with congenital long QT syndrome or other risk factors. Consider a non-QT-prolonging antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Ciprofloxacin with Gepirone?
MediHelp rates the interaction as moderate. Ciprofloxacin and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, so concurrent use may raise the risk of torsades de pointes. Gepirone labeling advises caution with other QT-prolonging drugs.
How serious is the interaction between Ciprofloxacin and Gepirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and electrolytes, and avoid the combination in patients with congenital long QT syndrome or other risk factors. Consider a non-QT-prolonging antibiotic.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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