Drug interactions
Ciprofloxacin + Goserelin
Severity: Moderate
Ciprofloxacin and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Androgen deprivation with goserelin may lengthen QT, and ciprofloxacin has a small QT effect, so the combination can increase the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Ciprofloxacin and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Goserelin belongs to Endocrine.
Why it happens
Additive QT prolongation: androgen deprivation alters cardiac repolarization and fluoroquinolones block cardiac potassium (hERG) channels.
What to do
Check baseline ECG and correct potassium and magnesium before starting. Use extra caution in patients with other QT risk factors, and consider an alternative antibiotic if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Goserelin
Frequently asked questions
Can I take Ciprofloxacin with Goserelin?
MediHelp rates the interaction as moderate. Ciprofloxacin and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval. Androgen deprivation with goserelin may lengthen QT, and ciprofloxacin has a small QT effect, so the combination can increase the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Ciprofloxacin and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before starting. Use extra caution in patients with other QT risk factors, and consider an alternative antibiotic if QTc is prolonged.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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