Drug interactions
Ciprofloxacin + Panobinostat
Severity: Major
Ciprofloxacin and Panobinostat: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat prolongs the QT interval and has labeled warnings against use with other QT-prolonging drugs. Ciprofloxacin adds to the risk of serious ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Ciprofloxacin and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Panobinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination and select an antibiotic without QT effects. If unavoidable, monitor ECG and keep potassium and magnesium in the normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Ciprofloxacin 250mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: drugs known to prolong QT interval; "drugs known to prolong QT interval") — electronic medicines compendium (UK SmPC)
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Ciprofloxacin with Panobinostat?
MediHelp rates the interaction as major. Ciprofloxacin and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Panobinostat prolongs the QT interval and has labeled warnings against use with other QT-prolonging drugs. Ciprofloxacin adds to the risk of serious ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Ciprofloxacin and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select an antibiotic without QT effects. If unavoidable, monitor ECG and keep potassium and magnesium in the normal range.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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