Drug interactions
Ciprofloxacin + Pentoxifylline
Severity: Minor
Ciprofloxacin and Pentoxifylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentoxifylline is a CYP1A2 substrate, and ciprofloxacin inhibits this enzyme. Pentoxifylline levels may rise, increasing gastrointestinal upset, dizziness, flushing or hypotension, and possibly bleeding tendency.
What this interaction means in plain words
Ciprofloxacin and Pentoxifylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Pentoxifylline belongs to Cardiovascular.
Why it happens
Ciprofloxacin inhibits CYP1A2-mediated metabolism of pentoxifylline and its metabolites.
What to do
Watch for pentoxifylline adverse effects such as hypotension or dizziness. Reduce the pentoxifylline dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Pentoxifylline
- Amifostine + Pentoxifylline Moderate
- Fluoxetine + Pentoxifylline Moderate
- Fluvoxamine + Pentoxifylline Moderate
- Insulin degludec / insulin aspart + Pentoxifylline Moderate
- Methoxsalen + Pentoxifylline Moderate
- Mexiletine + Pentoxifylline Moderate
Frequently asked questions
Can I take Ciprofloxacin with Pentoxifylline?
MediHelp rates the interaction as minor. Ciprofloxacin and Pentoxifylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pentoxifylline is a CYP1A2 substrate, and ciprofloxacin inhibits this enzyme. Pentoxifylline levels may rise, increasing gastrointestinal upset, dizziness, flushing or hypotension, and possibly bleeding tendency.
How serious is the interaction between Ciprofloxacin and Pentoxifylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for pentoxifylline adverse effects such as hypotension or dizziness. Reduce the pentoxifylline dose if these occur.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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