Drug interactions
Ciprofloxacin + Pretomanid
Severity: Minor
Ciprofloxacin and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits OAT3 in vitro, which could reduce renal secretion of ciprofloxacin and raise its levels. The clinical significance is not well established.
What this interaction means in plain words
Ciprofloxacin and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Pretomanid belongs to Anti Bacterial.
Why it happens
Inhibition of renal OAT3 by pretomanid may reduce the tubular secretion of ciprofloxacin.
What to do
No routine dose change is needed. Monitor for ciprofloxacin adverse effects such as CNS or tendon symptoms, particularly in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Ciprofloxacin with Pretomanid?
MediHelp rates the interaction as minor. Ciprofloxacin and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits OAT3 in vitro, which could reduce renal secretion of ciprofloxacin and raise its levels. The clinical significance is not well established.
How serious is the interaction between Ciprofloxacin and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for ciprofloxacin adverse effects such as CNS or tendon symptoms, particularly in renal impairment.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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