Drug interactions
Ciprofloxacin + Ruxolitinib
Severity: Moderate
Ciprofloxacin and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin inhibits CYP1A2 and to a lesser degree CYP3A4, which can raise ruxolitinib exposure and increase the risk of cytopenias such as thrombocytopenia and anemia. The effect is expected to be modest.
What this interaction means in plain words
Ciprofloxacin and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Ruxolitinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 (and CYP1A2) metabolism of ruxolitinib by ciprofloxacin.
What to do
Monitor complete blood counts more frequently when ciprofloxacin is combined with ruxolitinib. Consider reducing the ruxolitinib dose according to labeling if cytopenias develop, particularly with other CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Ciprofloxacin with Ruxolitinib?
MediHelp rates the interaction as moderate. Ciprofloxacin and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin inhibits CYP1A2 and to a lesser degree CYP3A4, which can raise ruxolitinib exposure and increase the risk of cytopenias such as thrombocytopenia and anemia. The effect is expected to be modest.
How serious is the interaction between Ciprofloxacin and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts more frequently when ciprofloxacin is combined with ruxolitinib. Consider reducing the ruxolitinib dose according to labeling if cytopenias develop, particularly with other CYP3A4 inhibitors.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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