Drug interactions
Ciprofloxacin + Tiotropium-olodaterol
Severity: Moderate
Ciprofloxacin and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin can prolong the QT interval, and olodaterol may add to arrhythmia risk through sympathetic stimulation and potassium lowering. The absolute risk is low but increases with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Ciprofloxacin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization together with beta2-mediated hypokalemia.
What to do
Correct hypokalemia and hypomagnesemia before and during treatment. Consider an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Ciprofloxacin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin can prolong the QT interval, and olodaterol may add to arrhythmia risk through sympathetic stimulation and potassium lowering. The absolute risk is low but increases with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Ciprofloxacin and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypokalemia and hypomagnesemia before and during treatment. Consider an ECG in patients with other QT risk factors.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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