Drug interactions
Ciprofloxacin + Vadadustat
Severity: Minor
Ciprofloxacin and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits OAT3 and ciprofloxacin is partly eliminated by renal tubular secretion. Ciprofloxacin exposure may increase modestly, although the clinical significance is probably small.
What this interaction means in plain words
Ciprofloxacin and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of OAT3-mediated renal tubular secretion of ciprofloxacin.
What to do
No routine adjustment is needed. Monitor for ciprofloxacin adverse effects, especially in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Ciprofloxacin with Vadadustat?
MediHelp rates the interaction as minor. Ciprofloxacin and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat inhibits OAT3 and ciprofloxacin is partly eliminated by renal tubular secretion. Ciprofloxacin exposure may increase modestly, although the clinical significance is probably small.
How serious is the interaction between Ciprofloxacin and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for ciprofloxacin adverse effects, especially in renal impairment.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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