Drug interactions
Ciprofloxacin + Valbenazine
Severity: Moderate
Ciprofloxacin and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine may prolong the QT interval at higher exposures, and ciprofloxacin adds a modest QT effect. The combination may raise arrhythmia risk in patients with other risk factors.
What this interaction means in plain words
Ciprofloxacin and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Valbenazine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Consider ECG monitoring in patients with cardiac disease or electrolyte disturbances. Correct potassium and magnesium before combining.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Ciprofloxacin with Valbenazine?
MediHelp rates the interaction as moderate. Ciprofloxacin and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine may prolong the QT interval at higher exposures, and ciprofloxacin adds a modest QT effect. The combination may raise arrhythmia risk in patients with other risk factors.
How serious is the interaction between Ciprofloxacin and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider ECG monitoring in patients with cardiac disease or electrolyte disturbances. Correct potassium and magnesium before combining.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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