Drug interactions
Cisapride + Cyclophosphamide
Severity: Minor
Cisapride and Cyclophosphamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide is not a significant CYP3A4 inhibitor, and it is a prodrug partly activated by CYP3A4. No clinically important increase in cisapride levels is expected.
What this interaction means in plain words
Cisapride and Cyclophosphamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cisapride belongs to Gastrointestinal Tract; Cyclophosphamide belongs to Oncology.
Why it happens
No established inhibition of CYP3A4 by cyclophosphamide; the legacy mechanism is theoretical.
What to do
No dose adjustment is needed. Monitor electrolytes if vomiting or diarrhea occurs during chemotherapy, as they affect QT risk with cisapride.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cisapride with Cyclophosphamide?
MediHelp rates the interaction as minor. Cisapride and Cyclophosphamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclophosphamide is not a significant CYP3A4 inhibitor, and it is a prodrug partly activated by CYP3A4. No clinically important increase in cisapride levels is expected.
How serious is the interaction between Cisapride and Cyclophosphamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor electrolytes if vomiting or diarrhea occurs during chemotherapy, as they affect QT risk with cisapride.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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