Drug interactions
Cisapride + Drospirenone
Severity: Minor
Cisapride and Drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is not a clinically relevant CYP3A4 inhibitor. It has antimineralocorticoid activity that can raise potassium, so a pharmacokinetic interaction with cisapride is not expected.
What this interaction means in plain words
Cisapride and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cisapride belongs to Gastrointestinal Tract; Drospirenone belongs to Endocrine.
Why it happens
Weak in vitro CYP inhibition only; no established effect on cisapride metabolism.
What to do
No specific action is needed. Check electrolytes if the patient has other QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Drospirenone
Frequently asked questions
Can I take Cisapride with Drospirenone?
MediHelp rates the interaction as minor. Cisapride and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone is not a clinically relevant CYP3A4 inhibitor. It has antimineralocorticoid activity that can raise potassium, so a pharmacokinetic interaction with cisapride is not expected.
How serious is the interaction between Cisapride and Drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Check electrolytes if the patient has other QT risk factors.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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