Drug interactions
Cisapride + Ponesimod
Severity: Major
Cisapride and Ponesimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponesimod slows heart rate and atrioventricular conduction, and cisapride prolongs the QT interval. Bradycardia combined with QT prolongation increases the risk of torsades de pointes.
What this interaction means in plain words
Cisapride and Ponesimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisapride belongs to Gastrointestinal Tract; Ponesimod belongs to Central Nervous System.
Why it happens
Pharmacodynamic combination of ponesimod-induced bradycardia and cisapride-induced QT prolongation.
What to do
Avoid the combination; if it is considered necessary, seek cardiology advice and obtain a baseline ECG with monitoring of heart rate and QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Ponesimod
- Fingolimod + Ponesimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Amiodarone + Ponesimod Major
- Amisulpride + Ponesimod Major
- Anagrelide + Ponesimod Major
- Anti-thymocyte + Ponesimod Major
Frequently asked questions
Can I take Cisapride with Ponesimod?
MediHelp rates the interaction as major. Cisapride and Ponesimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ponesimod slows heart rate and atrioventricular conduction, and cisapride prolongs the QT interval. Bradycardia combined with QT prolongation increases the risk of torsades de pointes.
How serious is the interaction between Cisapride and Ponesimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if it is considered necessary, seek cardiology advice and obtain a baseline ECG with monitoring of heart rate and QTc.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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