Drug interactions
Cisatracurium + Sevoflurane
Severity: Moderate
Cisatracurium and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as sevoflurane enhance neuromuscular blockade from non-depolarizing agents like cisatracurium. This lowers the dose needed and can prolong the duration of paralysis.
What this interaction means in plain words
Cisatracurium and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisatracurium belongs to Musculoskeletal; Sevoflurane belongs to Central Nervous System.
Why it happens
Sevoflurane depresses neuromuscular transmission and central motor tone, potentiating the postsynaptic block produced by cisatracurium.
What to do
Reduce cisatracurium dosing during sevoflurane anesthesia and guide dosing with train-of-four monitoring. Verify full recovery of neuromuscular function before extubation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisatracurium
Other interactions of Sevoflurane
Frequently asked questions
Can I take Cisatracurium with Sevoflurane?
MediHelp rates the interaction as moderate. Cisatracurium and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as sevoflurane enhance neuromuscular blockade from non-depolarizing agents like cisatracurium. This lowers the dose needed and can prolong the duration of paralysis.
How serious is the interaction between Cisatracurium and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce cisatracurium dosing during sevoflurane anesthesia and guide dosing with train-of-four monitoring. Verify full recovery of neuromuscular function before extubation.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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