Drug interactions
Cisplatin + Hydroxycarbamide
Severity: Moderate
Cisplatin and Hydroxycarbamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow function, so the combination can worsen cytopenias and increase infection and bleeding risk. Cisplatin also adds renal toxicity, and hydroxyurea is cleared renally, so accumulation of hydroxyurea is possible.
What this interaction means in plain words
Cisplatin and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Hydroxycarbamide belongs to Oncology.
Why it happens
Additive myelosuppression from two cytotoxic agents.
What to do
Monitor complete blood counts and renal function. Reduce the hydroxyurea dose or delay treatment if counts fall or renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Cisplatin with Hydroxycarbamide?
MediHelp rates the interaction as moderate. Cisplatin and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow function, so the combination can worsen cytopenias and increase infection and bleeding risk. Cisplatin also adds renal toxicity, and hydroxyurea is cleared renally, so accumulation of hydroxyurea is possible.
How serious is the interaction between Cisplatin and Hydroxycarbamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function. Reduce the hydroxyurea dose or delay treatment if counts fall or renal function declines.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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