Drug interactions
Cisplatin + Oxaliplatin
Severity: Major
Cisplatin and Oxaliplatin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are platinum agents with overlapping toxicities, and combining them may increase nephrotoxicity, ototoxicity, neurotoxicity and myelosuppression. Cross-resistance also limits the rationale for using both together.
What this interaction means in plain words
Cisplatin and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Oxaliplatin belongs to Oncology.
Why it happens
Additive platinum-related toxicity to renal, cochlear, neuronal and marrow cells.
What to do
Avoid concurrent use unless specified by a protocol. If used, monitor renal function, hearing, neurologic symptoms and blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Cisplatin 1 mg/ml concentrate for solution for Infusion - SmPC sections 4.3/4.5 (class statement: other platinum containing compounds; "Hypersensitivity to cisplatin or to any of the excipients listed in section 6.1 or other platinum containing compounds.") — electronic medicines compendium (UK SmPC)
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Cisplatin with Oxaliplatin?
MediHelp rates the interaction as major. Cisplatin and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are platinum agents with overlapping toxicities, and combining them may increase nephrotoxicity, ototoxicity, neurotoxicity and myelosuppression. Cross-resistance also limits the rationale for using both together.
How serious is the interaction between Cisplatin and Oxaliplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless specified by a protocol. If used, monitor renal function, hearing, neurologic symptoms and blood counts.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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