Drug interactions
Cisplatin + Selinexor
Severity: Moderate
Cisplatin and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes nausea, vomiting, fatigue, dizziness and confusion, and cisplatin is highly emetogenic and can cause neuropathy and ototoxicity. Combined use may worsen tolerability and gastrointestinal and neurological adverse effects.
What this interaction means in plain words
Cisplatin and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Selinexor belongs to Oncology.
Why it happens
Overlapping adverse effects; no pharmacokinetic mechanism is established.
What to do
Give prophylactic antiemetics, including a 5-HT3 antagonist, and monitor for neurological symptoms, hydration and electrolytes. Counsel patients about dizziness and confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cisplatin and Selinexor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Cisplatin with Selinexor?
MediHelp rates the interaction as moderate. Cisplatin and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes nausea, vomiting, fatigue, dizziness and confusion, and cisplatin is highly emetogenic and can cause neuropathy and ototoxicity. Combined use may worsen tolerability and gastrointestinal and neurological adverse effects.
How serious is the interaction between Cisplatin and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give prophylactic antiemetics, including a 5-HT3 antagonist, and monitor for neurological symptoms, hydration and electrolytes. Counsel patients about dizziness and confusion.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
