Drug interactions
Cisplatin + Trastuzumab deruxtecan
Severity: Moderate
Cisplatin and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan commonly causes neutropenia, and adding a myelosuppressive platinum agent can increase the frequency and severity of neutropenia and febrile neutropenia. Infection risk rises accordingly.
What this interaction means in plain words
Cisplatin and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression from the topoisomerase I inhibitor payload and cisplatin.
What to do
Monitor complete blood counts before each dose and delay or reduce doses for significant neutropenia. Consider growth factor support and counsel patients to report fever promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Cisplatin with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Cisplatin and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan commonly causes neutropenia, and adding a myelosuppressive platinum agent can increase the frequency and severity of neutropenia and febrile neutropenia. Infection risk rises accordingly.
How serious is the interaction between Cisplatin and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts before each dose and delay or reduce doses for significant neutropenia. Consider growth factor support and counsel patients to report fever promptly.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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