Drug interactions
Clarithromycin + Clevidipine
Severity: Minor
Clarithromycin and Clevidipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase exposure to clevidipine and enhance its blood pressure lowering effect. Hypotension, reflex tachycardia or edema may occur, but clevidipine is mainly cleared by blood and tissue esterases, so the effect is likely limited.
What this interaction means in plain words
Clarithromycin and Clevidipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Clevidipine belongs to Cardiovascular.
Why it happens
Clarithromycin inhibits CYP3A4, which plays only a minor role in clevidipine clearance because esterase hydrolysis predominates.
What to do
Titrate clevidipine to blood pressure response as usual and monitor blood pressure and heart rate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Clevidipine
Frequently asked questions
Can I take Clarithromycin with Clevidipine?
MediHelp rates the interaction as minor. Clarithromycin and Clevidipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin may increase exposure to clevidipine and enhance its blood pressure lowering effect. Hypotension, reflex tachycardia or edema may occur, but clevidipine is mainly cleared by blood and tissue esterases, so the effect is likely limited.
How serious is the interaction between Clarithromycin and Clevidipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine to blood pressure response as usual and monitor blood pressure and heart rate.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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