Drug interactions
Clarithromycin + Dicloxacillin
Severity: Minor
Clarithromycin and Dicloxacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin is bacteriostatic and may theoretically reduce the bactericidal effect of dicloxacillin. Clinical evidence of treatment failure is lacking.
What this interaction means in plain words
Clarithromycin and Dicloxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Dicloxacillin belongs to Anti Bacterial.
Why it happens
Pharmacodynamic antagonism: slowed bacterial growth reduces the effect of cell-wall-active beta-lactams.
What to do
No routine change is needed; monitor clinical response in severe infections and avoid unnecessary dual therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Dicloxacillin?
MediHelp rates the interaction as minor. Clarithromycin and Dicloxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin is bacteriostatic and may theoretically reduce the bactericidal effect of dicloxacillin. Clinical evidence of treatment failure is lacking.
How serious is the interaction between Clarithromycin and Dicloxacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor clinical response in severe infections and avoid unnecessary dual therapy.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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