Drug interactions
Clarithromycin + Dronabinol
Severity: Moderate
Clarithromycin and Dronabinol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase dronabinol concentrations, intensifying psychoactive effects such as drowsiness, dizziness, anxiety, confusion and tachycardia.
What this interaction means in plain words
Clarithromycin and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Dronabinol belongs to Central Nervous System.
Why it happens
Clarithromycin inhibits CYP3A4, which contributes to dronabinol metabolism.
What to do
Monitor for excessive CNS effects and tachycardia, and lower the dronabinol dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Clarithromycin with Dronabinol?
MediHelp rates the interaction as moderate. Clarithromycin and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may increase dronabinol concentrations, intensifying psychoactive effects such as drowsiness, dizziness, anxiety, confusion and tachycardia.
How serious is the interaction between Clarithromycin and Dronabinol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive CNS effects and tachycardia, and lower the dronabinol dose if these occur.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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