Drug interactions
Clarithromycin + Edoxaban
Severity: Moderate
Clarithromycin and Edoxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin increases edoxaban exposure modestly, which may raise bleeding risk. The effect is generally smaller than with other anticoagulant-inhibitor combinations.
What this interaction means in plain words
Clarithromycin and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Edoxaban belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux increases edoxaban absorption and reduces its elimination.
What to do
Monitor for bleeding signs; no routine dose change is needed for atrial fibrillation, but a dose reduction may be applied for VTE treatment per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Clarithromycin with Edoxaban?
MediHelp rates the interaction as moderate. Clarithromycin and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin increases edoxaban exposure modestly, which may raise bleeding risk. The effect is generally smaller than with other anticoagulant-inhibitor combinations.
How serious is the interaction between Clarithromycin and Edoxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs; no routine dose change is needed for atrial fibrillation, but a dose reduction may be applied for VTE treatment per labeling.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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