Drug interactions
Clarithromycin + Eluxadoline
Severity: Moderate
Clarithromycin and Eluxadoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin can raise eluxadoline concentrations, increasing the risk of its adverse effects, including constipation, nausea, abdominal pain and pancreatitis. Elevated exposure may be of particular concern in patients with hepatic impairment.
What this interaction means in plain words
Clarithromycin and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Clarithromycin inhibits OATP1B1 and P-glycoprotein transport and may reduce eluxadoline clearance.
What to do
Reduce eluxadoline to 75 mg twice daily during co-therapy and monitor for pancreatitis and GI symptoms. Consider an alternative antibiotic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Clarithromycin with Eluxadoline?
MediHelp rates the interaction as moderate. Clarithromycin and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin can raise eluxadoline concentrations, increasing the risk of its adverse effects, including constipation, nausea, abdominal pain and pancreatitis. Elevated exposure may be of particular concern in patients with hepatic impairment.
How serious is the interaction between Clarithromycin and Eluxadoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eluxadoline to 75 mg twice daily during co-therapy and monitor for pancreatitis and GI symptoms. Consider an alternative antibiotic if possible.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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