Drug interactions
Clarithromycin + Futibatinib
Severity: Major
Clarithromycin and Futibatinib: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin inhibits both CYP3A4 and P-glycoprotein, which can increase futibatinib exposure. This may worsen toxicities such as hyperphosphatemia, ocular effects and liver enzyme elevation.
What this interaction means in plain words
Clarithromycin and Futibatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Futibatinib belongs to Oncology.
Why it happens
Combined inhibition of CYP3A4 metabolism and P-gp efflux raises futibatinib concentrations.
What to do
Avoid the combination and use a non-inhibiting antibiotic. If unavoidable, monitor closely for futibatinib toxicity and interrupt or reduce the dose per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Futibatinib
Frequently asked questions
Can I take Clarithromycin with Futibatinib?
MediHelp rates the interaction as major. Clarithromycin and Futibatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin inhibits both CYP3A4 and P-glycoprotein, which can increase futibatinib exposure. This may worsen toxicities such as hyperphosphatemia, ocular effects and liver enzyme elevation.
How serious is the interaction between Clarithromycin and Futibatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inhibiting antibiotic. If unavoidable, monitor closely for futibatinib toxicity and interrupt or reduce the dose per labeling.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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