Drug interactions
Apalutamide + Futibatinib
Severity: Major
Apalutamide and Futibatinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may lower futibatinib exposure and reduce its antitumor activity in FGFR2-rearranged cholangiocarcinoma.
What this interaction means in plain words
Apalutamide and Futibatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Futibatinib belongs to Oncology.
Why it happens
Apalutamide induces CYP3A4 and P-glycoprotein, both involved in futibatinib disposition.
What to do
Avoid coadministration; choose an alternative to apalutamide if possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Futibatinib
Frequently asked questions
Can I take Apalutamide with Futibatinib?
MediHelp rates the interaction as major. Apalutamide and Futibatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may lower futibatinib exposure and reduce its antitumor activity in FGFR2-rearranged cholangiocarcinoma.
How serious is the interaction between Apalutamide and Futibatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; choose an alternative to apalutamide if possible.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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