Drug interactions
Futibatinib + Itraconazole
Severity: Major
Futibatinib and Itraconazole: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole, a dual P-gp and strong CYP3A4 inhibitor, increases futibatinib exposure. This may worsen hyperphosphatemia, ocular toxicity and other adverse effects.
What this interaction means in plain words
Futibatinib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Futibatinib belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Combined P-gp and CYP3A4 inhibition increases futibatinib absorption and reduces clearance.
What to do
Avoid coadministration and use an alternative antifungal. If unavoidable, monitor serum phosphate and for ocular and other toxicities, with dose reduction as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Futibatinib
Frequently asked questions
Can I take Futibatinib with Itraconazole?
MediHelp rates the interaction as major. Futibatinib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole, a dual P-gp and strong CYP3A4 inhibitor, increases futibatinib exposure. This may worsen hyperphosphatemia, ocular toxicity and other adverse effects.
How serious is the interaction between Futibatinib and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and use an alternative antifungal. If unavoidable, monitor serum phosphate and for ocular and other toxicities, with dose reduction as needed.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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