Drug interactions
Futibatinib + Posaconazole
Severity: Major
Futibatinib and Posaconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and also inhibits P-glycoprotein, and futibatinib is cleared in part by both pathways. Coadministration can raise futibatinib exposure and increase the frequency and severity of its toxicities, such as hyperphosphatemia and ocular effects.
What this interaction means in plain words
Futibatinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Futibatinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 metabolism and P-glycoprotein efflux of futibatinib by posaconazole increases futibatinib exposure.
What to do
Avoid the combination where possible and consider an antifungal that does not strongly inhibit CYP3A4 and P-gp. If it cannot be avoided, monitor closely for futibatinib adverse effects and reduce the dose or interrupt treatment as required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Futibatinib
Frequently asked questions
Can I take Futibatinib with Posaconazole?
MediHelp rates the interaction as major. Futibatinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole is a strong CYP3A4 inhibitor and also inhibits P-glycoprotein, and futibatinib is cleared in part by both pathways. Coadministration can raise futibatinib exposure and increase the frequency and severity of its toxicities, such as hyperphosphatemia and ocular effects.
How serious is the interaction between Futibatinib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider an antifungal that does not strongly inhibit CYP3A4 and P-gp. If it cannot be avoided, monitor closely for futibatinib adverse effects and reduce the dose or interrupt treatment as required.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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