Drug interactions
Clarithromycin + Granisetron
Severity: Moderate
Clarithromycin and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin can prolong the QT interval and granisetron may add to this effect. Clarithromycin also inhibits CYP3A4, which contributes to granisetron metabolism, though the clinical effect of this is limited.
What this interaction means in plain words
Clarithromycin and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation, with minor CYP3A4 inhibition.
What to do
Correct electrolytes and obtain an ECG in patients with cardiac risk factors. Consider an alternative macrolide or antiemetic if the QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Granisetron?
MediHelp rates the interaction as moderate. Clarithromycin and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin can prolong the QT interval and granisetron may add to this effect. Clarithromycin also inhibits CYP3A4, which contributes to granisetron metabolism, though the clinical effect of this is limited.
How serious is the interaction between Clarithromycin and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct electrolytes and obtain an ECG in patients with cardiac risk factors. Consider an alternative macrolide or antiemetic if the QTc is prolonged.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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