Drug interactions
Clarithromycin + Indacaterol-glycopyrronium
Severity: Moderate
Clarithromycin and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin inhibits CYP3A4 and P-glycoprotein and may raise indacaterol exposure, and it also prolongs the QT interval. This may increase beta-agonist cardiovascular effects and arrhythmia risk, although the increase at usual doses is modest.
What this interaction means in plain words
Clarithromycin and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein clearance of indacaterol plus additive QT prolongation.
What to do
Monitor heart rate, potassium and QTc in at-risk patients, and watch for tremor and palpitations. Consider azithromycin or a non-macrolide alternative if cardiac risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Clarithromycin and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin inhibits CYP3A4 and P-glycoprotein and may raise indacaterol exposure, and it also prolongs the QT interval. This may increase beta-agonist cardiovascular effects and arrhythmia risk, although the increase at usual doses is modest.
How serious is the interaction between Clarithromycin and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, potassium and QTc in at-risk patients, and watch for tremor and palpitations. Consider azithromycin or a non-macrolide alternative if cardiac risk is high.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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