Drug interactions
Clarithromycin + Osimertinib
Severity: Moderate
Clarithromycin and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may modestly raise osimertinib exposure, and both agents have QT-prolonging potential. This could increase the risk of adverse effects including arrhythmia.
What this interaction means in plain words
Clarithromycin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Osimertinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by clarithromycin reduces osimertinib clearance, with possible additive QT effects.
What to do
Prefer a non-CYP3A-inhibiting antibiotic. If coadministered, monitor ECG, electrolytes and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Clarithromycin with Osimertinib?
MediHelp rates the interaction as moderate. Clarithromycin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may modestly raise osimertinib exposure, and both agents have QT-prolonging potential. This could increase the risk of adverse effects including arrhythmia.
How serious is the interaction between Clarithromycin and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-CYP3A-inhibiting antibiotic. If coadministered, monitor ECG, electrolytes and adverse effects.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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