Drug interactions
Clarithromycin + Ospemifene
Severity: Moderate
Clarithromycin and Ospemifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ospemifene is metabolized by CYP3A4 and CYP2C9, and clarithromycin may raise its exposure. This could increase estrogen-agonist effects such as hot flushes and, in theory, thromboembolic or endometrial risks.
What this interaction means in plain words
Clarithromycin and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Ospemifene belongs to Endocrine.
Why it happens
CYP3A4 inhibition by clarithromycin reduces ospemifene metabolism.
What to do
Monitor for ospemifene adverse effects during short courses of clarithromycin. Avoid prolonged coadministration, or use an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Clarithromycin with Ospemifene?
MediHelp rates the interaction as moderate. Clarithromycin and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ospemifene is metabolized by CYP3A4 and CYP2C9, and clarithromycin may raise its exposure. This could increase estrogen-agonist effects such as hot flushes and, in theory, thromboembolic or endometrial risks.
How serious is the interaction between Clarithromycin and Ospemifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ospemifene adverse effects during short courses of clarithromycin. Avoid prolonged coadministration, or use an alternative antibiotic.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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