Drug interactions
Clarithromycin + Ripretinib
Severity: Moderate
Clarithromycin and Ripretinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A inhibitors raise exposure to ripretinib and its active metabolite. Adverse effects such as palmar-plantar erythrodysesthesia, hypertension and myalgia may become more frequent or severe.
What this interaction means in plain words
Clarithromycin and Ripretinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Ripretinib belongs to Oncology.
Why it happens
Clarithromycin inhibits CYP3A4 metabolism of ripretinib and its active metabolite.
What to do
Consider a non-CYP3A4-inhibiting antibiotic. If combined, monitor for ripretinib toxicity and reduce the dose if adverse reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Ripretinib
- Amobarbital + Ripretinib Major
- Apalutamide + Ripretinib Major
- Carbamazepine + Ripretinib Major
- Efavirenz + Ripretinib Major
- Enzalutamide + Ripretinib Major
- Phenytoin + Ripretinib Major
Frequently asked questions
Can I take Clarithromycin with Ripretinib?
MediHelp rates the interaction as moderate. Clarithromycin and Ripretinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A inhibitors raise exposure to ripretinib and its active metabolite. Adverse effects such as palmar-plantar erythrodysesthesia, hypertension and myalgia may become more frequent or severe.
How serious is the interaction between Clarithromycin and Ripretinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-CYP3A4-inhibiting antibiotic. If combined, monitor for ripretinib toxicity and reduce the dose if adverse reactions occur.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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