Drug interactions
Clarithromycin + Rosiglitazone
Severity: Minor
Clarithromycin and Rosiglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin might modestly raise rosiglitazone exposure, potentially adding to glucose lowering and fluid retention. Rosiglitazone is cleared mainly by CYP2C8, so the effect is likely small.
What this interaction means in plain words
Clarithromycin and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Rosiglitazone belongs to Endocrine.
Why it happens
Possible weak inhibition of CYP3A4-mediated minor metabolism of rosiglitazone.
What to do
No dose change is generally required. Monitor blood glucose and for edema.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Clarithromycin with Rosiglitazone?
MediHelp rates the interaction as minor. Clarithromycin and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin might modestly raise rosiglitazone exposure, potentially adding to glucose lowering and fluid retention. Rosiglitazone is cleared mainly by CYP2C8, so the effect is likely small.
How serious is the interaction between Clarithromycin and Rosiglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Monitor blood glucose and for edema.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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