Drug interactions
Clarithromycin + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Clarithromycin and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin is a strong CYP3A4 and P-gp inhibitor and may raise voxilaprevir and velpatasvir concentrations. The clinical importance is uncertain but higher exposure may increase adverse effects.
What this interaction means in plain words
Clarithromycin and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Clarithromycin inhibits CYP3A4 and P-gp, reducing metabolism and efflux of voxilaprevir.
What to do
Use an alternative macrolide such as azithromycin where appropriate. If clarithromycin is needed, monitor for gastrointestinal and hepatic adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Clarithromycin and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin is a strong CYP3A4 and P-gp inhibitor and may raise voxilaprevir and velpatasvir concentrations. The clinical importance is uncertain but higher exposure may increase adverse effects.
How serious is the interaction between Clarithromycin and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative macrolide such as azithromycin where appropriate. If clarithromycin is needed, monitor for gastrointestinal and hepatic adverse effects.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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