Drug interactions
Clarithromycin + Sonidegib
Severity: Major
Clarithromycin and Sonidegib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase sonidegib exposure, raising the risk of musculoskeletal toxicity including rhabdomyolysis and CK elevation.
What this interaction means in plain words
Clarithromycin and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Sonidegib belongs to Oncology.
Why it happens
Clarithromycin inhibits CYP3A4, reducing sonidegib metabolism.
What to do
Avoid strong CYP3A4 inhibitors with sonidegib. If use for a short period is unavoidable, monitor serum creatine kinase and watch for muscle symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Clarithromycin with Sonidegib?
MediHelp rates the interaction as major. Clarithromycin and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin may increase sonidegib exposure, raising the risk of musculoskeletal toxicity including rhabdomyolysis and CK elevation.
How serious is the interaction between Clarithromycin and Sonidegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inhibitors with sonidegib. If use for a short period is unavoidable, monitor serum creatine kinase and watch for muscle symptoms.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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